Lnc-GULP1–2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization

Abstract Backgrounds Long non-coding RNA is a novel group of non-protein coding transcripts over 200 nt in length. Recent studies have found that they are widely involved many pathological and physiological processes. In our previous study, we lnc-GULP1–2:1 was significantly down-regulated the ovarian cortical tissue patients with primary insufficiency predicted has regulatory effect on COL3A1. Results this mainly localized cytoplasm luteinized granulosa cells. The expression lower diminished reserve but substantially elevated polycystic ovary syndrome. Overexpression KGN cells inhibited cell proliferation, likely through cycle related genes CCND2 p16. Moreover, positively correlated level COL3A from different functions as well multiple lines. promoted COL3A1 its translocation into nucleus. Consistently, silencing also proliferation. Conclusions Lnc-GULP1–2:1 affects proliferation by regulating localization protein, may participate regulation follicle development. This study will provide new insight molecular mechanisms underlying follicular development, which help generate diagnostic therapeutic strategies for diseases to development disorders.